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CANCER

GENETIC CANCER RISK

Female Breast

High Risk

Colorectal

Elevated Risk

Endometrial

Elevated Risk

Gastric

Elevated Risk

Melanoma

Elevated Risk

Ovarian

Elevated Risk

Pancreatic

Elevated Risk

Prostate

Elevated Risk

Other

High Risk

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CANCER TYPE

AGE RANGE

CANCER RISK

RISK FOR GENERAL POPULATION

Overall Cancer Risk (male)

To age 5

14%-22%

0.1%

To age 20

25%-33%

0.4%

To age 50

60%-67%

3.4%

To age 70

79%-95%

20.3%

Overall Cancer Risk (female)

To age 5

3%-22%

0.1%

To age 20

15%-20%

0.3%

To age 50

73%-92%

5.4%

To age 70

82%-100%

19.2%

Overall Cancer Risk (male and female)

Risk for a second primary cancer within 10 years of a first cancer diagnosis

50%

NA

Female Breast

To age 70

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7.1%

Other - including Adrenocortical Carcinoma, Choroid Plexus Carcinoma, Soft Tissue Sarcoma, Bone Sarcoma, and Brain

To age 80

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NA

Colorectal

To age 80

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3.0%

Other - including non-Melanoma Skin, Lung, Leukemia, Lymphoma, Esophageal, Neuroblastoma, Thyroid, and Kidney

To age 80

Elevated risk

NA

Gastric

To age 80

Elevated risk, with a tendency towards young ages of diagnosis.

0.6%

Ovarian

To age 80

Possibly elevated

1.0%

Pancreatic

To age 80

Possibly elevated

1%

Prostate

To age 80

Possibly elevated

10.9%

Endometrial

To age 80

Possibly elevated

2.4%

Melanoma

To age 80

Possibly elevated

1.6%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Overall Cancer Risk

Provide education about the signs and symptoms of cancer

As needed

As needed

Female Breast

Breast awareness - Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness.

18 years

NA

Clinical breast examination

20 years, or at the age of the earliest diagnosis in the family if under age 20.

Every 6 to 12 months

Breast MRI with contrast and/or mammography with consideration of tomosynthesis

Age 20 for MRI. Age 30 for both MRI and mammography.

Annually

Consider risk-reducing mastectomy.

Individualized

NA

Other including Adrenocortical Carcinoma, Sarcomas, Brain tumors, Leukemia, Lymphoma, and other cancers, especially those for which there is a past diagnosis in the family.

Comprehensive physical and neurological examination

From birth

Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18

Whole body MRI, including brain

From birth

Annually

Abdominal and pelvic ultrasound

From birth

Every 3 to 4 months (from birth to age 18) and annually from age 18

Colorectal

Colonoscopy

25 years, or 5 years younger than the earliest colorectal cancer in the family, whichever comes first

Every 2 to 5 years

Gastric

Upper endoscopy

25 years, or individualized to a younger age based on family history

Every 2 to 5 years

Other including Ovarian, Endometrial, Prostate and Pancreatic cancer.

Comprehensive physical and neurological examination

From birth

Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18

Whole body MRI, including brain

From birth

Annually

Melanoma

Skin examination

18 years

Annually

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