Hereditary Cancer Syndromes > TP53
CANCER
GENETIC CANCER RISK
Female Breast
High Risk
Colorectal
Elevated Risk
Endometrial
Elevated Risk
Gastric
Elevated Risk
Melanoma
Elevated Risk
Renal
Elevated Risk
Pancreatic
Elevated Risk
Prostate
Elevated Risk
Other
High Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Overall Cancer Risk (male)
To age 5
14%-22%
0.1%
To age 20
25%-33%
0.4%
To age 50
60%-67%
3.4%
To age 70
79%-95%
20.3%
Overall Cancer Risk (female)
To age 5
3%-22%
0.1%
To age 20
15%-20%
0.3%
To age 50
73%-92%
5.4%
To age 70
82%-100%
19.2%
Overall Cancer Risk (male and female)
Risk for a second primary cancer within 10 years of a first cancer diagnosis
50%
NA
Female Breast
To age 70
85%, with a strong tendency towards very young ages of diagnosis - the large majority of cases occurring before age 45
7.4%
Other - including Adrenocortical Carcinoma, Choroid Plexus Carcinoma, Soft Tissue Sarcoma, Bone Sarcoma, and Brain
To age 80
Greatly increased risk, with a strong tendency towards young ages of diagnosis - sometimes in childhood
NA
Colorectal
To age 80
Elevated risk, with a strong tendency towards young ages of diagnosis - the median age of diagnosis is estimated to be 41
2.8%
Other - Including non-Melanoma Skin, Lung, Blood/Bone Marrow (Myelodysplastic Syndromes, Leukemia, Lymphoma), Esophageal, Neuroblastoma, and Thyroid
To age 80
Elevated risk
NA
Gastric
To age 80
Elevated risk, with a tendency towards young ages of diagnosis.
0.6%
Renal
To age 80
Possibly elevated
1.4%
Pancreatic
To age 80
Possibly elevated
1.1%
Prostate
To age 80
Possibly elevated
10.1%
Endometrial
To age 80
Possibly elevated
2.7%
Melanoma
To age 80
Possibly elevated
1.7%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Overall Cancer Risk
Provide education about the signs and symptoms of cancer
As needed
As needed
Female Breast
Breast awareness - Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness.
18 years
NA
Clinical breast examination
20 years, or at the age of the earliest diagnosis in the family if under age 20.
Every 6 to 12 months
Breast MRI with contrast and/or mammography with consideration of tomosynthesis
Age 20 for MRI. Age 30 for both MRI and mammography.
Annually
Consider risk-reducing mastectomy.
Individualized
NA
Other including Adrenocortical Carcinoma, Sarcomas, Brain tumors, Leukemia, Lymphoma, and other cancers, especially those for which there is a past diagnosis in the family.
Comprehensive physical and neurological examination
From birth
Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18
Whole body MRI, including brain
From birth
Annually
Abdominal and pelvic ultrasound
From birth
Every 3 to 4 months (from birth to age 18) and annually from age 18
Colorectal
Colonoscopy
25 years, or 5 years younger than the earliest colorectal cancer in the family, whichever comes first
Every 2 to 5 years
Gastric
Upper endoscopy
25 years, or individualized to a younger age based on family history
Every 2 to 5 years
Other including Endometrial, Prostate, Pancreatic, and Renal cancer.
Comprehensive physical and neurological examination
From birth
Every 3 to 4 months (from birth to age 18) and every 6 to 12 months from age 18
Whole body MRI, including brain
From birth
Annually
Melanoma
Skin examination
18 years
Annually
