Hereditary Cancer Syndromes > BMPR1A / SMAD4
CANCER
GENETIC CANCER RISK
Colorectal
High Risk
Gastric
High Risk
Other
Elevated Risk
CANCER TYPE
PROCEDURE
AGE TO BEGIN
RISK FOR GENERAL POPULATION
Colorectal
To age 42
20%-25%
<0.2%
To age 80
40%-50%
2.8%
Gastric
To age 80
Up to 21%
0.6%
Small Bowel
To age 80
Rare, but elevated risk
0.2%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
RISK FOR GENERAL POPULATION
Colorectal
Colonoscopy
12 to 15 years, or earlier if symptoms are present
Every 1 to 3 years, depending on age and findings
Monitor for rectal bleeding and/or anemia.
15 years, or earlier if symptoms are present
Annually
Gastric
Upper endoscopy
12 to 15 years, or earlier if symptoms are present
Every 1 to 3 years, depending on age and findings
Small Bowel
Capsule endoscopy
15 years
Every 1 to 2 years
CANCER
GENETIC CANCER RISK
Colorectal
High Risk
Gastric
High Risk
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Other
High Risk
CANCER TYPE
PROCEDURE
AGE TO BEGIN
RISK FOR GENERAL POPULATION
Colorectal
To age 42
20%-25%
<0.2%
To age 80
40%-50%
2.8%
Gastric
To age 80
Up to 21%
0.6%
Small Bowel
To age 80
Rare, but elevated risk
0.2%
Other - Hereditary Hemorrhagic Telangiectasia
All ages
HHT is associated with a high risk for life threatening arteriovenous malformations of the lungs, brain and liver as well as nosebleeds.
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CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Colonoscopy
12 to 15 years, or earlier if symptoms are present
Every 1 to 3 years, depending on age and findings
Monitor for rectal bleeding and/or anemia.
15 years, or earlier if symptoms are present
Annually
Gastric
Upper Endoscopy
12 to 15 years
Every 1 to 3 years, depending on age and findings
Small Bowel
Capsule endoscopy
15 years
Every 1 to 2 years
Other - Hereditary Hemorrhagic Telangiectasia
Multiple screenings recommended, which may include brain MRI, contrast echocardiogram, and chest CT.
Some screenings are recommended within the first 6 months of life
Varies
CANCER
GENETIC CANCER RISK
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