Hereditary Cancer Syndromes >   BRIP1, BARD1, RAD51C, RAD51D

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CANCER

GENETIC CANCER RISK

Female Breast

High Risk

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CANCER

GENETIC CANCER RISK

Ovarian

High Risk

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION 

Female Breast

To age 80

20%

10.2%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION 

Ovarian

To age 80

5.8%

1.0%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION *

Ovarian

To age 50

1.0%

0.2%

6.7%

1.0%

To age 80

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION *

Ovarian

To age 50

2.3%

0.2%

To age 80

14.8%

1.0%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION *

Female Breast

Currently there are no specific medical management guidelines for breast cancer risk in mutation carriers. However, the increased risk for breast cancer warrants consideration of individualized breast cancer risk-reduction strategies, such as the modification of standard population screening recommendations by starting screening at younger ages, performing screenings at greater frequency, and utilizing more sensitive technologies such as breast MRI.

Individualized

NA

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION *

Ovarian

Consider bilateral salpingo-oophorectomy (BSO).

45 to 50 years, or earlier if there is a family history of ovarian cancer at a younger age

NA

Other than consideration of BSO, currently there are no specific medical management recommendations for ovarian cancer risk in mutation carriers. However, the increase in risk may warrant consideration of individualized ovarian cancer risk-reduction strategies using other currently available options, such as surveillance and the use of risk-reducing agents.

Individualized

NA

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Ovarian

Consider bilateral salpingo-oophorectomy (BSO).

45 to 50 years, or earlier if there is a family history of ovarian cancer at a younger age

NA

Other than consideration of BSO, currently there are no specific medical management recommendations for ovarian cancer risk in mutation carriers. However, the increase in risk may warrant consideration of individualized ovarian cancer risk-reduction strategies using other currently available options, such as surveillance and the use of risk-reducing agents.

Individualized

NA

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Ovarian

Consider bilateral salpingo-oophorectomy (BSO).

45 to 50 years, or earlier if there is a family history of ovarian cancer at a younger age

NA

Other than consideration of BSO, currently there are no specific medical management recommendations for ovarian cancer risk in mutation carriers. However, the increase in risk may warrant consideration of individualized ovarian cancer risk-reduction strategies using other currently available options, such as surveillance and the use of risk-reducing agents.

Individualized

NA

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