Hereditary Cancer Syndromes > CDH1
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Gastric (male)
To age 80
67%-70%
0.6%
Gastric (female)
To age 80
56%-83%
0.6%
Female Breast
To age 50
10%
2.1%
To age 80
39%-52%
10.7%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Gastric
Gastrectomy, after baseline endoscopy
18 to 40 years, or individualized to a younger age if a relative has been diagnosed younger than age 25
NA
Surveillance with endoscopies including targeted and random biopsies is recommended for patients delaying or declining gastrectomy, and may be appropriate for those with no family history of diffuse gastric cancer
Individualized
Every 6 to 12 months
Treat Helicobacter pylori infection if present
Individualized
NA
Female Breast
Breast awareness - Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness.
18 years
NA
Clinical breast examination
25 years
Annually
Mammogram
30 to 40 years, or 5 to 10 years younger than the youngest diagnosis in the family, whichever comes first
Annually
Consider breast MRI with contrast
30 years, or 5 to 10 years younger than the youngest diagnosis in the family, whichever comes first
Annually
Consider risk-reducing mastectomy.
Between 30 and 60 years
NA
