Hereditary Cancer Syndromes >  CDKN2A (p16INK4a), CDKN2A (p14ARF), CDK4

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CANCER

GENETIC CANCER RISK

Melanoma

High Risk

Pancreatic

High Risk

Gene Cancer Risk Table
CDKN2A (p161NK4a)
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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION *

Melanoma

To age 50

14%-50%

0.3%

To age 80

28%-76%

1.6%

Pancreatic

To age 75

Up to 17%

0.7%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Melanoma

Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen.

Infancy

Ongoing

Whole-body skin examinations conducted by the patient or family member.

10 years

Monthly

Clinical skin examinations by an appropriately trained provider, with consideration of whole-body photography and close-up photography of atypical nevi for ongoing comparison.

10 years

Every 6 to 12 months

Pancreatic

Consider available options for pancreatic cancer screening, including endoscopic ultrasonography (EUS) and MRI/magnetic resonance cholangiopancreatography (MRCP). It is recommended that patients who are candidates for pancreatic cancer screening be managed by a multidisciplinary team with experience in screening for pancreatic cancer, preferably within research protocols.

Age 40, or 10 years younger than the earliest age of pancreatic cancer diagnosis in the family

Annually

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Provide education about ways to reduce pancreatic cancer risk, such as not smoking and losing weight.

Individualized

Individualized

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CANCER

GENETIC CANCER RISK

Melanoma

High Risk

Pancreatic

Elevated Risk

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION *

Melanoma

To age 50

14%-50%

0.3%

To age 80

28%-76%

1.6%

Pancreatic

To age 75

Elevated risk

0.7%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Melanoma

Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen.

Infancy

Ongoing

Whole-body skin examinations conducted by the patient or family member.

10 years

Monthly

Clinical skin examinations by an appropriately trained provider, with consideration of whole-body photography and close-up photography of atypical nevi for ongoing comparison.

10 years

Every 6 to 12 months

Pancreatic

Consider available options for pancreatic cancer screening, including endoscopic ultrasonography (EUS) and MRI/magnetic resonance cholangiopancreatography (MRCP). It is recommended that patients who are candidates for pancreatic cancer screening be managed by a multidisciplinary team with experience in screening for pancreatic cancer, preferably within research protocols.

Age 40, or 10 years younger than the earliest age of pancreatic cancer diagnosis in the family

Annually

Provide education about ways to reduce pancreatic cancer risk, such as not smoking and losing weight.

Individualized

Individualized

medical_managment-key.png

CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Melanoma

Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen.

Infancy

Ongoing

Whole-body skin examinations conducted by the patient or family member.

10 years

Monthly

Clinical skin examinations by an appropriately trained provider, with consideration of whole-body photography and close-up photography of atypical nevi for ongoing comparison.

10 years

Every 6 to 12 months

Pancreatic

Currently there are no specific medical management guidelines for pancreatic cancer risk in mutation carriers.

NA

NA

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