CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Melanoma
Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen.
Infancy
Ongoing
Whole-body skin examinations conducted by the patient or family member.
10 years
Monthly
Comprehensive skin examination by a dermatologist, with total body photography and dermoscopy.
10 years
Every 6 to 12 months
Pancreatic
Consider available options for pancreatic cancer screening, including endoscopic ultrasonography (EUS) and MRI/magnetic resonance cholangiopancreatography (MRCP). It is recommended that patients who are candidates for pancreatic cancer screening be managed by a multidisciplinary team with experience in screening for pancreatic cancer, preferably within research protocols.
Age 40, or 10 years younger than the earliest age of pancreatic cancer diagnosis in the family
Annually
Provide education about ways to reduce pancreatic cancer risk, such as not smoking and losing weight.
Individualized
Individualized
CANCER
GENETIC CANCER RISK
Melanoma
High Risk
Pancreatic
Elevated Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Melanoma
To age 50
14%-50%
0.3%
To age 80
28%-76%
1.6%
Pancreatic
To age 75
Elevated risk
0.8%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Melanoma
Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen.
Infancy
Ongoing
Whole-body skin examinations conducted by the patient or family member.
10 years
Monthly
Comprehensive skin examination by a dermatologist, with total body photography and dermoscopy.
10 years
Every 6 to 12 months
Pancreatic
Consider available options for pancreatic cancer screening, including endoscopic ultrasonography (EUS) and MRI/magnetic resonance cholangiopancreatography (MRCP). It is recommended that patients who are candidates for pancreatic cancer screening be managed by a multidisciplinary team with experience in screening for pancreatic cancer, preferably within research protocols.
Age 40, or 10 years younger than the earliest age of pancreatic cancer diagnosis in the family
Annually
Provide education about ways to reduce pancreatic cancer risk, such as not smoking and losing weight.
Individualized
Individualized
CANCER
GENETIC CANCER RISK
Melanoma
High Risk
Pancreatic
Elevated Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Melanoma
To age 50
14%-50%
0.3%
To age 80
28%-76%
1.6%
Pancreatic
To age 75
Elevated risk
0.8%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Melanoma
Education about the importance of skin protection, such as sun avoidance, protective clothing and sunscreen.
Infancy
Ongoing
Whole-body skin examinations conducted by the patient or family member.
10 years
Monthly
Clinical skin examinations by an appropriately trained provider, with consideration of whole-body photography and close-up photography of atypical nevi for ongoing comparison.
10 years
Every 6 to 12 months
Pancreatic
Currently there are no specific medical management guidelines for pancreatic cancer risk in mutation carriers.
NA
NA
