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CANCER

GENETIC CANCER RISK

Other

High Risk

Renal

Elevated Risk

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CANCER TYPE

PROCEDURE

CANCER RISK

RISK FOR GENERAL POPULATION *

Renal

To age 80

2%-5%

1.4%

Malignant Angiomyolipoma

To age 80

Rare, but elevated risk

<0.1%

Other - Non-malignant features of TSC

All ages

TSC is associated with many life-threatening non-malignant clinical features, some of which may require medical intervention as early as infancy (see Overview).

NA

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Renal

Abdominal imaging with MRI (preferred) or CT, with and without contrast1

12 years

Every 3 to 5 years

Malignant Angiomyolipoma

Abdominal MRI

At time of diagnosis of TSC

Every 1 to 3 years

Consider everolimus therapy for asymptomatic, growing angiomyolipoma measuring >3 cm in diameter

Individualized

NA

Other - Non-malignant features of TSC

Multiple screenings recommended, which may include comprehensive physical exam, brain MRI, echocardiogram, chest CT, and evaluations for neuropsychiatric disorders.

At time of diagnosis of TSC

Varies