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CANCER

GENETIC CANCER RISK

Other

High Risk

Renal

High Risk

Skin

Elevated Risk

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

RISK FOR GENERAL POPULATION *

Renal

To age 80

9.7%

1.4%

Melanoma

To age 80

Elevated risk for skin melanoma

1.7%

Other - Non-malignant features of BHDS

All ages

BHDS is associated with a high risk for lung cysts and life-threatening spontaneous pneumothorax (lung collapse), as well as benign skin tumors.

NA

FLCN

Associated Syndrome

Birt-Hogg-Dube Syndrome (BHDS).

Core Cancer Risk(s)

Renal Cancer and Melanoma

Inheritance 

Autosomal Dominant 

Prevalence

Unknown

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Renal

Abdominal imaging with MRI (preferred) or CT, with and without contrast2, 11

Age 20

Every 1 to 3 years

Melanoma

Currently there are no specific medical management recommendations for melanoma risk in mutation carriers. However, the increased risk for melanoma warrants consideration of risk-reduction strategies, including frequent self-examination of the skin, consideration of clinical skin examinations, and minimizing exposure to the sun and other sources of UV radiation.9, 10

Individualized

NA

Other - Non-malignant features of BHDS

Evaluation for lung cysts and attention to the risk for pneumothorax, as well as dermatological consultation

At diagnosis

Individualized