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CTNNA1
Associated Syndrome
Hereditary Diffuse Gastric Cancer syndrome (HDGC)
Core Cancer Risk(s)
Diffuse Gastric Cancer
Inheritance
Autosomal Dominant
Prevalence
1 in 2912
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Gastric
To age 80
High Risk
0.6%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Gastric
Endoscopy with targeted and random biopsies
Individualized
Annually
Consider gastrectomy, after baseline endoscopy
Individualized
NA
Consider testing and treating for Helicobacter pylori infection if present
Individualized
NA
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