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CTNNA1
Associated Syndrome
Hereditary Diffuse Gastric Cancer syndrome (HDGC)
Core Cancer Risk(s)
Diffuse Gastric Cancer
Inheritance
Autosomal Dominant
Prevalence
1 in 2912

CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Gastric
To age 80
49%-57%
0.6%

CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Gastric
Endoscopy with targeted and random biopsies
Individualized
Annually
Consider gastrectomy, after baseline endoscopy
Individualized
N/A
Consider testing and treating for Helicobacter pylori infection if present
Individualized
N/A
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