CTNNA1

Associated Syndrome

Hereditary Diffuse Gastric Cancer syndrome (HDGC)

Core Cancer Risk(s)

Diffuse Gastric Cancer

Inheritance 

Autosomal Dominant 

Prevalence

1 in 2912

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CANCER

GENETIC CANCER RISK

Gastric

High Risk

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CANCER TYPE

PROCEDURE

CANCER RISK

RISK FOR GENERAL POPULATION *

Gastric

To age 80

High Risk

0.6%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Gastric

Endoscopy with targeted and random biopsies

Individualized

Annually

Consider gastrectomy, after baseline endoscopy

Individualized

NA

Consider testing and treating for Helicobacter pylori infection if present

Individualized

NA