Hereditary Cancer Syndromes > Familial Polyposis APC
CANCER
GENETIC CANCER RISK
Colorectal
High Risk
Gastric
Elevated Risk
Pancreatic
Elevated Risk
Other
High Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
FAP to age 21
7%
<0.1%
FAP to age 50
93%
0.3%
FAP to age 80
>99%
3.0%
AFAP to age 80
>70%
3.0%
Other - Desmoid Tumors
To age 80
10%-30%
<0.04%
Small Bowel/Periampullary
To age 80
4%-12%
0.2%
Hepatoblastoma
To age 5
1%-2%
<0.001%
Gastric
To age 80
Slightly increased risk in Western cultures, but may be significantly increased in cultures with a higher baseline gastric cancer rate.
0.6%
Thyroid
To age 80
1%-2%
1.1%
Central Nervous System
To age 80
1%
0.5%
Pancreatic
To age 80
Possibly elevated risk
1%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Sigmoidoscopy or colonoscopy
10 to 15 years
Annually
Colorectal surgical evaluation and counseling.
Based on cancer diagnosis and/or polyp number, size and histology
NA
Consider chemoprevention with NSAIDs to reduce adenoma burden after surgery.
NA
NA
Other - Desmoid Tumors
Abdominal palpation with consideration of abdominal MRI or CT.
1 to 3 years post-colectomy
Every 5 to 10 years, or with symptoms
Small Bowel/Periampullary
Upper endoscopy, including complete visualization of the ampulla of Vater
20 to 25 years, or earlier if patient had a colectomy before age 20 years
Every 4 years
Hepatoblastoma
Consider liver palpation, abdominal ultrasound, and alpha-fetoprotein (AFP) measurement.
Infancy
Every 3 to 6 months during first 5 years of life
Gastric
Upper endoscopy
20 to 25 years, or earlier if patient had a colectomy before age 20 years
Every 4 years
Thyroid
Thyroid examination and/or consider ultrasound.
Late teens
Annually
Central Nervous System
Physical examination
Individualized
Annually
Pancreatic
Currently there are no specific medical management guidelines for pancreatic cancer risk in mutation carriers.
NA
NA
