Hereditary Cancer Syndromes > Familial Polyposis APC
CANCER
GENETIC CANCER RISK
Colorectal
High Risk
Gastric
Elevated Risk
Endocrine
Elevated Risk
Other
High Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
FAP to age 21
7%
<0.1%
FAP to age 50
93%
0.4%
FAP to age 80
>99%
2.8%
AFAP to age 80
>70%
2.8%
Other - Desmoid Tumors
To age 80
10%-30%
<0.04%
Small Bowel/Periampullary
To age 80
4%-12%
0.2%
Hepatoblastoma
To age 5
1%-2%
<0.001%
Gastric
To age 80
1.3%, but significantly higher in Japanese and Korean populations
0.6%
Thyroid
To age 80
2.6%-8.5%
1.1%
Central Nervous System
To age 80
1%
0.5%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Colonoscopy
10 to 15 years
Annually
Colorectal surgical evaluation and counseling.
Based on cancer diagnosis and/or polyp number, size and histology
NA
Consider chemoprevention with NSAIDs to reduce adenoma burden after surgery.
NA
NA
Other - Desmoid Tumors
Abdominal MRI or CT
When symptoms are present
At least annually
Small Bowel/
Periampullary
Upper endoscopy, with consideration of capsule endoscopy to visualize the entire small bowel
20 to 25 years, or earlier if there is a family history of small bowel adenomas or cancer
Every 3 to 5 years
Hepatoblastoma
Consider liver palpation, abdominal ultrasound, and alpha-fetoprotein (AFP) measurement.
Infancy
Every 3 to 6 months during first 5 years of life
Gastric
Consider screening for patients with high risk features
Individualized
Individualized
Thyroid
Thyroid ultrasound
Late teens
Every 2 to 5 years, or consider more often if there is a family history of thyroid cancer
Central Nervous System
Patient education about the importance of quickly seeking attention for signs and symptoms of neurologic cancer
Individualized
NA
