Hereditary Cancer Syndromes > MUTYH
CANCER
GENETIC CANCER RISK
Colorectal
High Risk
Other
High Risk
CANCER
GENETIC CANCER RISK
Colorectal
Elevated Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
To age 80
43%-100%
2.8%
Small Bowel/
Periampullary
To age 80
5%
0.2%
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
To age 80
3.4% to 10%
2.8%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Colonoscopy
25 to 30 years, or earlier if indicated by family history
Every 1 to 2 years
Colorectal surgical evaluation and counseling.
Based on cancer diagnosis and/or polyp number, size and histology
N/A
Small Bowel/
Periampullary
Upper endoscopy, with consideration of capsule endoscopy to visualize the entire small bowel
30 to 35 years
Every 3 to 5 years
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Currently there are no medical management guidelines for colorectal cancer risk in patients with a single MUTYH mutation unless colorectal cancer has been diagnosed in a first-degree relative
N/A
N/A
