CANCER
GENETIC CANCER RISK
Colorectal
Elevated Risk
Female Breast
Elevated Risk
Endometrial
Elevated Risk
Other
Elevated Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
To age 80
Elevated risk
2.8%
Female Breast
To age 80
Elevated risk
10.7%
Endometrial
To age 80
Possibly elevated risk
2.6%
Small Bowel
To age 80
Possibly elevated risk
0.2%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Colonoscopy
25 to 30 years
Every 2 to 3 years
Colorectal surgical evaluation and counseling.
Based on cancer diagnosis and/or polyp number, size and histology
N/A
Female Breast
Currently there are no specific medical management guidelines for female breast cancer risk in biallelic mutation carriers. However, the possibility of an increased risk for breast cancer warrants consideration of individualized breast cancer risk-reduction strategies, such as the modification of standard population screening recommendations by starting screening at younger ages and/or performing screenings at greater frequency
N/A
N/A
Endometrial
Patient education about the importance of quickly seeking attention for endometrial cancer symptoms, such as abnormal bleeding
Individualized
N/A
Consider transvaginal ultrasound
After menopause
Individualized
Small Bowel
Upper endoscopy, including complete visualization of the entire small bowel
Baseline at 30 to 35 years
Every 3 to 5 years