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Hereditary Cancer Syndromes > POLD1, POLE, MSH3

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Summary Cancer Risk Table
POLD1, POLE, and, MSH3 Biallelic
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CANCER

GENETIC CANCER RISK

Colorectal

High Risk

Cancer Risk Table
POLD1, POLE, and, MSH3 Biallelic
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CANCER TYPE

AGE RANGE

CANCER RISK

RISK FOR GENERAL POPULATION

Colorectal

To age 80

Elevated risk

2.8%

Cancer Risk Management Table
POLD1, POLE, and, MSH3 Biallelic
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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Colorectal

Colonoscopy

25 to 30 years

Every 2 to 3 years

Colorectal surgical evaluation and counseling.

Based on cancer diagnosis and/or polyp number, size and histology

NA

MSH3 Monoallelic gene

Carrier Status for MSH3-associated Cancer Risk 

  • Individuals with a mutation in only one copy of the MSH3 gene (a monoallelic mutation) are not believed to have any increased risk for cancer over people in the general population.

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