Hereditary Cancer Syndromes > POLD1, POLE, MSH3
CANCER
GENETIC CANCER RISK
Colorectal
High Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
To age 70
50%
1.8%
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
To age 70
90%
1.8%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Colonoscopy
25 to 30 years
Every 2 to 3 years
Colorectal surgical evaluation and counseling.
Based on cancer diagnosis and/or polyp number, size and histology
N/A
CANCER
GENETIC CANCER RISK
Colorectal
Elevated Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
To age 80
Elevated risk
2.8%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Colonoscopy
25 to 30 years
Every 2 to 3 years
Colorectal surgical evaluation and counseling.
Based on cancer diagnosis and/or polyp number, size and histology
N/A
Carrier Status for MSH3-associated Cancer Risk
-
Individuals with a mutation in only one copy of the MSH3 gene (a monoallelic mutation) are not believed to have any increased risk for cancer over people in the general population.