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CANCER

GENETIC CANCER RISK

Breast

High Risk

Colorectal

High Risk

Endocrine

High Risk

Endometrial

High Risk

Other

High Risk

Renal

High Risk

Skin

High Risk

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CANCER TYPE

AGE RANGE

CANCER RISK

RISK FOR GENERAL POPULATION

Overall Cancer Risk (male and female)

To age 70

85%-89%

20.0%

Female Breast

To age 70

77%-85%

7.4%

Endometrial

To age 70

19%-28%

1.9%

Thyroid

To age 70

21%-38%

1.0%

Colorectal

To age 70

9%-16%

1.8%

Renal

To age 70

15%-34%

0.9%

Melanoma

To age 70

Up to 6%

1.1%

Other - Non-malignant features of PHTS

All ages

PHTS is associated with non-malignant clinical features, some of which may require medical intervention as early as infancy (see Overview)

NA

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CANCER TYPE

AGE RANGE

CANCER RISK

RISK FOR GENERAL POPULATION

Overall Cancer Risk

Comprehensive physical examination, with particular attention to thyroid cancer. General education about the signs and symptoms of cancer.

18 years or 5 years before the youngest age of a PHTS-related cancer in family

Annually

Female Breast

Breast awareness - Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness.

18 years

NA

Clinical breast examination

25 years, or 5 to 10 years younger than the earliest diagnosis in the family, whichever comes first.

Every 6 to 12 months

Mammography with consideration of tomosynthesis and breast MRI with contrast

30 to 35 years, or 5 to 10 years younger than the earliest diagnosis in the family, whichever comes first

Annually

Consider risk-reducing mastectomy.

Individualized

NA

Endometrial

Patient education about the importance of quickly seeking attention for endometrial cancer symptoms, such as abnormal bleeding or menstrual cycle irregularities

Individualized

NA

Consider transvaginal ultrasound.

After menopause

Individualized

Consider screening with endometrial biopsies.

Age 35

Every 1 to 2 years

Consider hysterectomy.

After completion of childbearing

NA

Thyroid

Thyroid ultrasound

Age 7

Annually

Colorectal

Colonoscopy

35 years, or 5 to 10 years younger than the earliest diagnosis in the family if a family member was diagnosed under age 40

Every 5 years

Renal

Consider renal ultrasound

40 years

Every 1 to 2 years

Melanoma

Dermatology exam

Individualized

Annually

Other - Non-malignant features of PHTS

Comprehensive physical examination. Dermatologic management may be indicated for some patients. Consider psychomotor assessment in children and brain MRI if there are symptoms.

18 years or earlier if symptoms are present

Annually

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