Hereditary Cancer Syndromes > PTEN
CANCER
GENETIC CANCER RISK
Breast
High Risk
Colorectal
High Risk
Endocrine
High Risk
Endometrial
High Risk
Other
High Risk
Renal
High Risk
Skin
High Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Overall Cancer Risk (male and female)
To age 70
70%-89%
20.1%
Female Breast
To age 70
60%-85%
7.5%
Endometrial
To age 70
6%-33%
1.9%
Thyroid
To age 70
17%-38%
0.9%
Colorectal
To age 70
5%-16%
1.8%
Renal
To age 70
3%-34%
0.9%
Melanoma
To age 70
6%-12%
1.0%
Other - Non-malignant features of PHTS
All ages
PHTS is associated with non-malignant clinical features, some of which may require medical intervention as early as infancy (see Overview)
NA
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Overall Cancer Risk
Comprehensive physical examination, with particular attention to thyroid cancer. General education about the signs and symptoms of cancer.
18 years or 5 years before the youngest age of a PHTS-related cancer in family
Annually
Female Breast
Breast awareness - Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness.
18 years
NA
Clinical breast examination
25 years, or 5 to 10 years younger than the earliest diagnosis in the family, whichever comes first.
Every 6 to 12 months
Mammography and breast MRI with contrast
30 to 35 years, or 5 to 10 years younger than the earliest diagnosis in the family, whichever comes first
Annually
Consider risk-reducing mastectomy.
Individualized
NA
Endometrial
Patient education about the importance of quickly seeking attention for endometrial cancer symptoms, such as abnormal bleeding or menstrual cycle irregularities
Individualized
NA
Consider transvaginal ultrasound.
After menopause
Individualized
Consider screening with endometrial biopsies.
Age 35
Every 1 to 2 years
Consider hysterectomy.
After completion of childbearing
NA
Thyroid
Thyroid ultrasound
Age 7
Annually
Colorectal
Colonoscopy
35 years, or 5 to 10 years younger than the earliest diagnosis in the family if a family member was diagnosed under age 40
Every 5 years
Renal
Consider renal ultrasound
40 years
Every 1 to 2 years
Melanoma
Dermatology exam
Individualized
Annually
Other - Non-malignant features of PHTS
Comprehensive physical examination. Dermatologic management may be indicated for some patients. Consider psychomotor assessment in children and brain MRI if there are symptoms.
18 years or earlier if symptoms are present
Annually
