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CANCER

GENETIC CANCER RISK

Colorectal

Elevated Risk

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CANCER TYPE

AGE RANGE

CANCER RISK

RISK FOR GENERAL POPULATION

Colorectal

To age 80

Elevated risk

3.0%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Colorectal

RNF43 mutation carriers who do meet WHO criteria for a diagnosis of SPS should be managed based on guidelines from NCCN and other professional societies. These guidelines include recommendations for frequent colonoscopy screenings, beginning at young ages, and surgical evaluation based on family history and personal polyp history.

When identified as meeting WHO criteria for SPS

NA

Currently there are no specific management guidelines for colorectal cancer risk in RNF43 mutation carriers who do not meet WHO criteria for a diagnosis of SPS. However, the possibility of an increased risk for colorectal cancer warrants consideration of individualized colorectal cancer risk-reduction strategies, such as the modification of standard population screening recommendations by starting screening at younger ages and/or performing screening more frequently.

NA

NA