Hereditary Cancer Syndromes > STK11
CANCER
GENETIC CANCER RISK
Colorectal
High Risk
Endometrial
High Risk
Female Breast
High Risk
Gastric
High Risk
Ovarian
High Risk
Pancreatic
High Risk
Lung
High Risk
Other
High Risk
CANCER TYPE
AGE RANGE
CANCER RISK
RISK FOR GENERAL POPULATION
Colorectal
To age 70
39%
1.8%
Pancreatic
To age 70
11%-36%
0.6%
Female Breast
To age 70
32%-54%
7.5%
Gastric
To age 70
29%
0.3%
Small Bowel
To age 70
13%
0.1%
Ovarian
To age 70
18%-21%
0.6%
Endometrial
To age 70
9%
1.9%
Cervical
To age 70
10%
0.5%
Testicular
To age 70
Elevated risk
0.4%
Lung
To age 70
7%-17%
2.0%
CANCER TYPE
PROCEDURE
AGE TO BEGIN
FREQUENCY
Colorectal
Colonoscopy
Baseline at age 8 to 10 years, or earlier if symptomatic, with follow-up as needed
Every 2 to 3 years after age 18
Pancreatic
Magnetic resonance cholangiopancreatography (MRCP) with contrast or endoscopic ultrasound (EUS).
30 to 35 years, or 10 years younger than the earliest age of diagnosis in the family
Annually
Female Breast
Breast awareness - Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness.
18 years
NA
Clinical breast examination
30 years
Every 6 months
Mammography and breast MRI with contrast
30 years
Annually
Consider risk-reducing mastectomy
Individualized
NA
Gastric
Upper endoscopy
Baseline at age 8 to 10 years, or earlier if symptomatic, with follow-up as needed
Every 2 to 3 years after age 18
Small Bowel
Small bowel visualization with CT, MRI enterography or video capsule endoscopy
Baseline at 8 to 10 years, or earlier if symptomatic, with follow-up as needed, but no later than age 18
Every 2 to 3 years after age 18
Ovarian
Physical exam, monitor for precocious puberty
Age 8
Annually
Pelvic examination with consideration of pelvic ultrasound
18 to 20 years
Annually
Endometrial
Pelvic examination with endometrial biopsy if abnormal bleeding
18 to 20 years
Annually
Cervical
Pelvic examination and pap smear
18 to 20 years
Annually
Consider total hysterectomy (including uterus and cervix).
After completion of childbearing
NA
Testicular
Physical and testicular examination and observation for feminizing changes.
Age 10
Annually
Lung
Provide education about symptoms and smoking cessation.
As needed
As needed
