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CANCER

GENETIC CANCER RISK

Colorectal

High Risk

Endometrial

High Risk

Female Breast

High Risk

Gastric

High Risk

Ovarian

High Risk

Pancreatic

High Risk

Other

High Risk

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CANCER TYPE

AGE RANGE

CANCER RISK

RISK FOR GENERAL POPULATION

Colorectal

To age 70

39%

1.8%

Pancreatic

To age 70

11%-36%

0.5%

Female Breast

To age 70

45%-50%

7.1%

Gastric

To age 70

29%

0.4%

Small Bowel

To age 70

13%

0.1%

Ovarian

To age 70

18%-21%

0.7%

Endometrial

To age 70

9%

1.7%

Cervical

To age 70

10%

0.5%

Testicular

To age 70

Elevated risk

0.4%

Lung

To age 70

15%-17%

2.2%

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CANCER TYPE

PROCEDURE

AGE TO BEGIN

FREQUENCY

Colorectal

Colonoscopy

Baseline at age 8, or earlier if symptomatic, with follow-up as needed

Every 2 to 3 years after age 18

Pancreatic

Magnetic resonance cholangiopancreatography (MRCP) with contrast or endoscopic ultrasound (EUS).

30 to 35 years, or 10 years younger than the earliest age of diagnosis in the family

Every 1 to 2 years

Female Breast

Breast awareness - Women should be familiar with their breasts and promptly report changes to their healthcare provider. Periodic, consistent breast self-examination (BSE) may facilitate breast awareness.

18 years

NA

Clinical breast examination

25 years

Every 6 months

Mammography and breast MRI with contrast

25 years

Annually

Gastric

Upper endoscopy

Baseline at age 8, or earlier if symptomatic, with follow up as needed

Every 2 to 3 years after age 18

Small Bowel

Small bowel visualization with CT, MRI enterography or video capsule endoscopy4

Baseline at 8 years, or earlier if symptomatic, with follow up as needed, but no later than age 18

Every 2 to 3 years after age 18

Ovarian

Physical exam, monitor for precocious puberty

Childhood

Annually

Pelvic examination

18 to 25 years

Annually

Consider transvaginal ultrasound.

25 years

Annually

Endometrial

Pelvic examination

18 to 25 years

Annually

Consider transvaginal ultrasound.

25 years

Annually

Cervical

Pap smear

18 to 25 years

Annually

Testicular

Physical and testicular examination and observation for feminizing changes.

Childhood

Annually

Lung

Provide education about symptoms and smoking cessation.

As needed

As needed

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